منابع مشابه
Pharmacology of the HMG-CoA reductase inhibitors
Pleiotropic effects are now described for the 3-hydroxy-3methylglutaryl-coenzyme A reductase inhibitors (or statins) that might have utility in the context of chronic inflammatory autoimmune disease. Here we discuss the pharmacology and established uses of statins and in this context describe potential anti-inflammatory and immune-modulatory effects. An extensive in vitro data set defines roles...
متن کاملHMG-CoA reductase inhibitors and renal function.
Experimental Evidence for a Role of Dyslipidemia in Renal Injury and for a Renal Protective Effect of Statins T he presence of lipids in renal cells upregulates intracellular signaling pathways involved in inflammatory and fibrogenic responses, both of which are components of progressive renal injury. Lipids activate various growth factors that cause mesangial cell proliferation. Mesangial cell...
متن کاملAnti-inflammatory Activity of Hmg Co a Reductase Inhibitors: a Comparative Study
Objective: The purpose of the present study was to reveal the potential pleotropic anti-inflammatory activity of two hmg-co Reductase inhibitors, Rosuvastatin and atorvastatin in comparison with standard drug diclofenac. Methods: The method used for screening anti-inflammatry activity was In vitro human red blood cell membrane stabilization method. Results: The results of our study revealed tha...
متن کاملThe use of HMG Co-A reductase inhibitors following acute myocardial infarction in hospital practice.
Treatment with a HMG-CoA reductase inhibitor (statin) following a myocardial infarction has been shown to reduce the incidence of subsequent coronary revascularisation, myocardial infarction and cardiovascular death. The majority (89%) of patients admitted to the coronary care unit of our hospital received a fasting cholesterol check as part of a routine coronary care unit protocol. However, ou...
متن کاملDrug Utilization and Evaluation of Hmg-co a Reductase Inhibitors in Tertiary Care Teaching Hospital
A prospective study was conducted to evaluate the drug utilization of HMG-CoA reductase inhibitors (statins) in a tertiary care teaching hospital to ensure rational use, safety, prescribing pattern and economic strategy for 6 months, in which 440 patients prescribed with statins were recruited for the study and the data were collected and analyzed statistically. Statins were more prescribed in ...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2003
ISSN: 0306-5251
DOI: 10.1046/j.1365-2125.2003.01867.x